So this game has come a long way since its inception. I've been doing a lot of accessibility updates so that visually impaired people can play it more easily. If you are visually impaired, this game should be fully accessible to you, but make sure you have your screen reader going before you start it up.
I started up a wiki for regular updates and to search as an encyclopedia for it (its getting in depth enough to where I think it needs it now).
Getting Started: The first screen you are presented with is the start screen, click start to begin. If the game does not start for you, you may have some compatibility issues with the WebAudio API. Try starting with the link at the bottom of the start screen if you run into that. It should bypass those features (which, right now is just panned audio).
Difficulty: Start the game by selecting your difficulty. You won't be able to get very far at first unless you select Easy. As you build up your heirloom gear and prestige you can use the higher difficulties when you start.
Prestige: As you venture through the dungeons you have the ability to add prestige effects to your character that improve your abilities. These will be preserved in future plays if you end up resetting your game by eating a Humble Pie. This is the prestige mechanism and the only way to keep permanent bonuses on your character. Each merchant will have prestige foods for sale (such as Toughen Muffin) and a Humble Pie, along with other items. In order for these to save between playthroughs, you must have cookies enabled, and if you clear your cookies, they go away, sorry.
Controls: Explore moves to the next scene, and uses 1 Energy. Search searches the current scene and uses 1 Energy. Each scene can only be searched once. Potion consumes 1 potion and heals wounds. Food consumes 1 food and heals fatigue. Fight fights the enemy in the current scene. Run attempts to run away from the current enemy and uses 1 Energy for each attempt. You cannot run from boss fights.
There is a lot to this game and I'm not sure what all needs to be explained, so check the wiki or post a comment with questions.